| JOR | Equipo local | RS | Equipo visitante | Fecha | PJ | GC | TA | TR | PG |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Santos Laguna | 0 - 0 | Pachuca | 01/06/2012 | SS | - | - | - | - |
| 2 | Atlante | 1 - 2 | Santos Laguna | 01/13/2012 | NC | - | - | - |  |
| 3 | Santos Laguna | 1 - 0 | Chiapas | 01/20/2012 | SS | - | - | - | |
| 4 | Tijuana | 1 - 3 | Santos Laguna | 01/28/2012 | NC | - | - | - | |
| 5 | Santos Laguna | 2 - 1 | Pumas | 02/03/2012 | SS | - | - | - | |
| 6 | Morelia | 3 - 1 | Santos Laguna | 02/09/2012 | NC | - | - | - | - |
| 7 | Santos Laguna | 1 - 1 | Monterrey | 02/17/2012 | SS | - | - | - | - |
| 8 | Chivas | 2 - 1 | Santos Laguna | 02/25/2012 | SS |  1 |
- | - | - |
| 9 | Santos Laguna | 5 - 2 | San Luis | 03/02/2012 | T | 1 |
 |
- | |
| 10 | Santos Laguna | 3 - 1 | Puebla | 03/09/2012 | T | 2 |
- | - | |
| 11 | Cruz Azul | 0 - 1 | Santos Laguna | 03/16/2012 | NC | - | - | - | |
| 12 | Santos Laguna | 2 - 0 | Gallos Blancos | 03/23/2012 | T | 1 |
- | - | |
| 13 | Toluca | 1 - 3 | Santos Laguna | 03/31/2012 | NC | - | - | - | |
| 14 | Santos Laguna | 1 - 1 | Estudiantes U.A.G | 04/06/2012 | NC | - | - | - | - |
| 15 | América | 3 - 1 | Santos Laguna | 04/13/2012 | NC | - | - | - | - |
| 16 | Santos Laguna | 3 - 0 | Tigres | 04/20/2012 | T | - | - | - | |
| 17 | Atlas | 1 - 3 | Santos Laguna | 04/27/2012 | NC | - | - | - | |
| Cuartos | Chiapas | 3 - 4 | Santos Laguna | 05/02/2012 | NC | - | - | - | |
| Cuartos | Santos Laguna | 2 - 1 | Chiapas | 05/05/2012 | SS | - | - | - | |
| Semi Final | Tigres | 1 - 1 | Santos Laguna | 05/09/2012 | SS | - | - | - | - |
| Semi Final | Santos Laguna | 2 - 2 | Tigres | 05/12/2012 | SS | - | - | - | - |